The 1299 Panigale, with its 1285 cm3 Superquadro engine, raised the standards once again in terms of performance for supersports bikes on the international market. Thanks to incredible torque with a value of 144.6 Nm at 8,750 rpm, a dry weight of 166.5 kg (367 lb) and maximum power of 205 hp at 10,500 rpm. With an extremely high power to weight ratio, the 1299 Panigale is a new benchmark standard for very high performance bikes.

Both the 2017 models of the 1299 Panigale and 1299 Panigale S feature the latest Ducati Traction Control (DTC) and Ducati Wheelie Control (DWC) known as EVO versions. These systems , introduced for the first time on the exclusive 1299 Panigale S Anniversario, bring performance and active safety to unprecedented levels on the Bologna-built Superbike. The new DTC and DWC EVO act according to a brand new algorithm which enables each to intervene faster and with greater precision.